Version 5.4
Homo sapiens Gene: FOXF1
Summary
InnateDB Gene IDBG-45352.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXF1
Gene Name forkhead box F1
Synonyms ACDMPV; FKHL5; FREAC1
Species Homo sapiens
Ensembl Gene ENSG00000103241
Encoded Proteins
IDBP-45354
forkhead box F1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:86510527-86515418
Strand Forward strand
Band q24.1
Transcripts
ENST00000262426 ENSP00000262426
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0001763 morphogenesis of a branching structure
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0003197 endocardial cushion development
GO:0003214 cardiac left ventricle morphogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007224 smoothened signaling pathway
GO:0007368 determination of left/right symmetry
GO:0007494 midgut development
GO:0007498 mesoderm development
GO:0007507 heart development
GO:0009887 organ morphogenesis
GO:0010811 positive regulation of cell-substrate adhesion
GO:0014822 detection of wounding
GO:0016337 single organismal cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0031016 pancreas development
GO:0043305 negative regulation of mast cell degranulation
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048286 lung alveolus development
GO:0048371 lateral mesodermal cell differentiation
GO:0048557 embryonic digestive tract morphogenesis
GO:0048565 digestive tract development
GO:0048566 embryonic digestive tract development
GO:0048613 embryonic ectodermal digestive tract morphogenesis
GO:0048617 embryonic foregut morphogenesis
GO:0050728 negative regulation of inflammatory response
GO:0051145 smooth muscle cell differentiation
GO:0051150 regulation of smooth muscle cell differentiation
GO:0060425 lung morphogenesis
GO:0060426 lung vasculature development
GO:0060438 trachea development
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060446 branching involved in open tracheal system development
GO:0060461 right lung morphogenesis
GO:0060463 lung lobe morphogenesis
GO:0060841 venous blood vessel development
GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development
GO:0071345 cellular response to cytokine stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0072001 renal system development
GO:0072189 ureter development
GO:0090131 mesenchyme migration
GO:0097070 ductus arteriosus closure
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042812
View Gene Order
ENSBTAG00000000009
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt Q12946
TrEMBL
UniProt Splice Variant
Entrez Gene 2294
UniGene Hs.155591 Hs.619376
RefSeq NM_001451
HUGO HGNC:3809
OMIM 601089
CCDS CCDS10957
HPRD
IMGT
EMBL AC009108 AF085342 AF085343 AK314167 BC089442 U13219
GenPept AAC50399 AAC61576 AAH89442 BAG36851
RNA Seq Atlas 2294

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca