Version 5.4
Homo sapiens Gene: UBOX5
Summary
InnateDB Gene IDBG-45539.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBOX5
Gene Name U-box domain containing 5
Synonyms RNF37; UBCE7IP5; UIP5
Species Homo sapiens
Ensembl Gene ENSG00000185019
Encoded Proteins
IDBP-45543
U-box domain containing 5
IDBP-45545
U-box domain containing 5
IDBP-363466
U-box domain containing 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 enzymes and may play a role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:3107573-3160196
Strand Reverse strand
Band p13
Transcripts
ENST00000217173 ENSP00000217173
ENST00000348031 ENSP00000311726
ENST00000449731 ENSP00000404364
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0034450 ubiquitin-ubiquitin ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0016567 protein ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt O94941
TrEMBL A2A2Q6
UniProt Splice Variant
Entrez Gene 22888
UniGene Hs.654646
RefSeq NM_001267584 NM_014948 NM_199415
HUGO HGNC:17777
OMIM
CCDS CCDS13046 CCDS13047
HPRD
IMGT
EMBL AB020667 AK022444 AL121891 BC000515 BC046122 CH471133 CR457089
GenPept AAH00515 AAH46122 BAA74883 BAG51073 CAC09908 CAC09909 CAG33370 EAX10550 EAX10551
RNA Seq Atlas 22888

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca