Version 5.4
Homo sapiens Gene: GSTK1
Summary
InnateDB Gene IDBG-45743.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSTK1
Gene Name glutathione S-transferase kappa 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197448
Encoded Proteins
IDBP-45747
glutathione S-transferase kappa 1
IDBP-293997
glutathione S-transferase kappa 1
IDBP-387015
glutathione S-transferase kappa 1
IDBP-387017
glutathione S-transferase kappa 1
IDBP-387018
glutathione S-transferase kappa 1
IDBP-480017
glutathione S-transferase kappa 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:143244093-143270854
Strand Forward strand
Band q34
Transcripts
ENST00000358406 ENSP00000351181
ENST00000409500 ENSP00000386944
ENST00000436038 ENSP00000408341
ENST00000443571 ENSP00000415813
ENST00000442394 ENSP00000406802
ENST00000479303 ENSP00000431049
ENST00000494735
ENST00000473649
ENST00000489654
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 39 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0005102 receptor binding
GO:0015035 protein disulfide oxidoreductase activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0030855 epithelial cell differentiation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029864
View Gene Order
ENSBTAG00000009839
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00480
Glutathione metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00982
Drug metabolism pathway
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9JNT3
UniProt Splice Variant
Entrez Gene 373156
UniGene Hs.390667
RefSeq NM_001143679 NM_001143680 NM_001143681 NM_015917
HUGO HGNC:16906
OMIM 602321
CCDS CCDS47730 CCDS47731 CCDS47732 CCDS5877
HPRD
IMGT
EMBL AC073342
GenPept
RNA Seq Atlas 373156

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca