InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CASP2

Summary

InnateDB Gene

IDBG-45836.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP2

Gene Name

caspase 2, apoptosis-related cysteine peptidase

Synonyms

CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57

Species

Homo sapiens

Ensembl Gene

ENSG00000106144

Encoded Proteins

IDBP-45838

caspase 2, apoptosis-related cysteine peptidase

IDBP-45840

caspase 2, apoptosis-related cysteine peptidase

IDBP-244659

caspase 2, apoptosis-related cysteine peptidase

IDBP-809164

caspase 2, apoptosis-related cysteine peptidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26341399

[Mus musculus] Nlrp3 and Casp2 are required for endoplasmic reticulum stress-induced inflammation.

Entrez Gene

Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer\'s disease, Huntington\'s disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:143288215-143307696

Strand

Forward strand

Band

q34

Transcripts

ENST00000310447	ENSP00000312664
ENST00000350623	ENSP00000340030
ENST00000392925	ENSP00000376656
ENST00000493642
ENST00000481483
ENST00000472067
ENST00000619992	ENSP00000481929

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	35 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process

Biological Process

GO:0001554	luteolysis
GO:0003407	neural retina development
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007420	brain development
GO:0007568	aging
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016485	protein processing
GO:0035234	ectopic germ cell programmed cell death
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0071260	cellular response to mechanical stimulus
GO:0097190	apoptotic signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097194	execution phase of apoptosis
GO:2001235	positive regulation of apoptotic signaling pathway