InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: U2AF1

Summary

InnateDB Gene

IDBG-4654.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

U2AF1

Gene Name

U2 small nuclear RNA auxiliary factor 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000160201

Encoded Proteins

IDBP-4656

U2 small nuclear RNA auxiliary factor 1

IDBP-4658

U2 small nuclear RNA auxiliary factor 1

IDBP-233758

U2 small nuclear RNA auxiliary factor 1

IDBP-477595

U2 small nuclear RNA auxiliary factor 1

IDBP-474128

U2 small nuclear RNA auxiliary factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:43092956-43107587

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000380276	ENSP00000369629
ENST00000291552	ENSP00000291552
ENST00000398137	ENSP00000381205
ENST00000464750	ENSP00000420672
ENST00000459639	ENSP00000418705
ENST00000475639
ENST00000478282
ENST00000471250
ENST00000486519
ENST00000463599
ENST00000496462
ENST00000468039

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 139 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	139 [view]
Protein-Protein	138 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006397	mRNA processing
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing