Version 5.4
Homo sapiens Gene: TIMM10
Summary
InnateDB Gene IDBG-46728.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIMM10
Gene Name translocase of inner mitochondrial membrane 10 homolog (yeast)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134809
Encoded Proteins
IDBP-46730
translocase of inner mitochondrial membrane 10 homolog (yeast)
IDBP-592763
translocase of inner mitochondrial membrane 10 homolog (yeast)
IDBP-603711
translocase of inner mitochondrial membrane 10 homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:57528463-57530803
Strand Reverse strand
Band q12.1
Transcripts
ENST00000257245 ENSP00000257245
ENST00000525587 ENSP00000435678
ENST00000525158 ENSP00000433627
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042803 protein homodimerization activity
GO:0051087 chaperone binding
Biological Process
GO:0006626 protein targeting to mitochondrion
GO:0007605 sensory perception of sound
GO:0044267 cellular protein metabolic process
GO:0045039 protein import into mitochondrial inner membrane
GO:0072321 chaperone-mediated protein transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005744 mitochondrial inner membrane presequence translocase complex
GO:0005758 mitochondrial intermembrane space
GO:0042719 mitochondrial intermembrane space protein transporter complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027076
View Gene Order
ENSBTAG00000024701
Not yet available
Pathways
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P62072
TrEMBL
UniProt Splice Variant
Entrez Gene 26519
UniGene Hs.603158
RefSeq NM_012456
HUGO HGNC:11814
OMIM 602251
CCDS CCDS7959
HPRD 03768
IMGT
EMBL AF150089 AF152354 AK289751 BC032133 CH471076
GenPept AAD39995 AAF15104 AAH32133 BAF82440 EAW73753
RNA Seq Atlas 26519

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca