Homo sapiens Gene: ACSF3

Summary
InnateDB Gene IDBG-47147.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol ACSF3
Gene Name acyl-CoA synthetase family member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000176715
Encoded Proteins
IDBP-47149 acyl-CoA synthetase family member 3
IDBP-47151 acyl-CoA synthetase family member 3
IDBP-294371 acyl-CoA synthetase family member 3
IDBP-595648 acyl-CoA synthetase family member 3
IDBP-595796 acyl-CoA synthetase family member 3
IDBP-601145 acyl-CoA synthetase family member 3
IDBP-747089
IDBP-588170 acyl-CoA synthetase family member 3
IDBP-587562 acyl-CoA synthetase family member 3
IDBP-596643 acyl-CoA synthetase family member 3
IDBP-587680 acyl-CoA synthetase family member 3
IDBP-595763 acyl-CoA synthetase family member 3
Entrez Gene
Summary This gene encodes a member of the acyl-CoA synthetase family of enzymes that activate fatty acids by catalyzing the formation of a thioester linkage between fatty acids and coenzyme A. The encoded protein is localized to mitochondria, has high specificity for malonate and methylmalonate and possesses malonyl-CoA synthetase activity. Mutations in this gene are a cause of combined malonic and methylmalonic aciduria. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16: 89154783-89222254
Strand Forward strand
Band q24.3
Transcripts
ENST00000378345  ENSP00000367596
ENST00000317447  ENSP00000320646
ENST00000393145 
ENST00000406948  ENSP00000384627
ENST00000537895  ENSP00000439201
ENST00000537290  ENSP00000440734
ENST00000540697  ENSP00000445397
ENST00000541755  ENSP00000457301
ENST00000542688  ENSP00000446281
ENST00000544543  ENSP00000442781
ENST00000538340  ENSP00000445870
ENST00000543676  ENSP00000442683
ENST00000537116 
ENST00000537155 
ENST00000535176  ENSP00000443428
ENST00000562204 
ENST00000562750 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
 
Predicted by orthology
Total 1 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0016878 acid-thiol ligase activity
GO:0090409 malonyl-CoA synthetase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008152 metabolic process
GO:0090410 malonate catabolic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000015016 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000015968 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q4G176 
TrEMBL F5GX20 F5H2G6 F5H362 F5H3B2 F5H5A1 F5H755 H0YH37 H3BTS0
UniProt Splice Variant
Entrez Gene 197322 
UniGene Hs.670100 Hs.737565
RefSeq NM_001127214  NM_001243279  NM_174917 
HUGO 27288 
OMIM 614245
CCDS CCDS10974 
HPRD 14117
IMGT
EMBL AC009113 AC135782 AK075499 AK290963 BC028399 BC072391 CH471184
GenPept AAH28399  AAH72391  BAC11654  BAF83652  EAW66744 
ImmGen ACSF3 (murine) 
RNA Seq Atlas 197322