Version 5.4
Homo sapiens Gene: SFI1
Summary
InnateDB Gene IDBG-4730.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SFI1
Gene Name Sfi1 homolog, spindle assembly associated (yeast)
Synonyms hSfi1p; PISD; PPP1R139
Species Homo sapiens
Ensembl Gene ENSG00000198089
Encoded Proteins
IDBP-228598
Sfi1 homolog, spindle assembly associated (yeast)
IDBP-228600
Sfi1 homolog, spindle assembly associated (yeast)
IDBP-373102
Sfi1 homolog, spindle assembly associated (yeast)
IDBP-373113
Sfi1 homolog, spindle assembly associated (yeast)
IDBP-373114
Sfi1 homolog, spindle assembly associated (yeast)
IDBP-373117
Sfi1 homolog, spindle assembly associated (yeast)
IDBP-373121
Sfi1 homolog, spindle assembly associated (yeast)
IDBP-373125
Sfi1 homolog, spindle assembly associated (yeast)
IDBP-373127
Sfi1 homolog, spindle assembly associated (yeast)
IDBP-373129
Sfi1 homolog, spindle assembly associated (yeast)
IDBP-474093
Sfi1 homolog, spindle assembly associated (yeast)
IDBP-600135
Sfi1 homolog, spindle assembly associated (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 22:31488688-31618586
Strand Forward strand
Band q12.2
Transcripts
ENST00000357852
ENST00000382162
ENST00000400289 ENSP00000383146
ENST00000400288 ENSP00000383145
ENST00000432498 ENSP00000402679
ENST00000443011 ENSP00000401199
ENST00000411518 ENSP00000391339
ENST00000444859 ENSP00000411793
ENST00000450787 ENSP00000389364
ENST00000452250 ENSP00000405541
ENST00000417682 ENSP00000398871
ENST00000425671 ENSP00000416931
ENST00000465646
ENST00000465437
ENST00000524296 ENSP00000430488
ENST00000486708
ENST00000476010
ENST00000484806
ENST00000478887
ENST00000467357
ENST00000488883
ENST00000466991
ENST00000491973
ENST00000463436
ENST00000495107
ENST00000474741
ENST00000476577
ENST00000464333
ENST00000540643 ENSP00000443025
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019902 phosphatase binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0010923 negative regulation of phosphatase activity
Cellular Component
GO:0005814 centriole
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023764
View Gene Order
ENSBTAG00000008996
Not yet available
Pathways
NETPATH
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_115566
Cell Cycle pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 9814
UniGene Hs.62209 Hs.679749
RefSeq NM_001007467 NM_001258325 NM_001258326 NM_001258327 NM_014775 XM_005261868 XM_005261869 XM_005261872 XM_005261873 XM_006724388 XM_006724389 XM_006724390
HUGO HGNC:29064
OMIM 612765
CCDS CCDS43004 CCDS43005 CCDS58803 CCDS58804
HPRD 11550
IMGT
EMBL
GenPept
RNA Seq Atlas 9814

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca