Version 5.4
Homo sapiens Gene: A2LD1
Summary
InnateDB Gene IDBG-47427.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol A2LD1
Gene Name gamma-glutamylamine cyclotransferase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134864
Encoded Proteins
IDBP-47431
AIG2-like domain 1
IDBP-372957
AIG2-like domain 1
IDBP-704106
IDBP-704225
IDBP-704362
IDBP-704236
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene aids in the proteolytic degradation of crosslinked fibrin by breaking down isodipeptide L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin degradation. The reaction catalyzed by the encoded gamma-glutamylaminecyclotransferase produces 5-oxo-L-proline and a free alkylamine. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:100530164-100589528
Strand Reverse strand
Band q32.3
Transcripts
ENST00000376250 ENSP00000365426
ENST00000455100 ENSP00000410449
ENST00000492399 ENSP00000471342
ENST00000467518 ENSP00000472246
ENST00000471912 ENSP00000471716
ENST00000464500 ENSP00000471322
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003839 gamma-glutamylcyclotransferase activity
Biological Process
GO:0042219 cellular modified amino acid catabolic process
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041625
View Gene Order
ENSBTAG00000046552
Not yet available
Cross-References
SwissProt
TrEMBL M0R0M3 M0R217
UniProt Splice Variant
Entrez Gene 87769
UniGene
RefSeq NM_001195087 NM_033110
HUGO HGNC:25100
OMIM 613378
CCDS CCDS45066
HPRD
IMGT
EMBL AL136526 AL356966 AL359085
GenPept
RNA Seq Atlas 87769

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca