Version 5.4
Homo sapiens Gene: CHMP1A
Summary
InnateDB Gene IDBG-47864.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHMP1A
Gene Name charged multivesicular body protein 1A
Synonyms CHMP1; PCH8; PCOLN3; PRSM1; VPS46-1; VPS46A
Species Homo sapiens
Ensembl Gene ENSG00000131165
Encoded Proteins
IDBP-234334
charged multivesicular body protein 1A
IDBP-588131
charged multivesicular body protein 1A
IDBP-598260
charged multivesicular body protein 1A
IDBP-599883
charged multivesicular body protein 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:89644431-89657845
Strand Reverse strand
Band q24.3
Transcripts
ENST00000397901 ENSP00000380998
ENST00000547687
ENST00000535997 ENSP00000442120
ENST00000549139
ENST00000550102 ENSP00000449243
ENST00000549328 ENSP00000447899
ENST00000551981
ENST00000548650
ENST00000547614
ENST00000550872
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0019904 protein domain specific binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000910 cytokinesis
GO:0006351 transcription, DNA-templated
GO:0006508 proteolysis
GO:0007034 vacuolar transport
GO:0007076 mitotic chromosome condensation
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0016458 gene silencing
GO:0045014 negative regulation of transcription by glucose
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005769 early endosome
GO:0005815 microtubule organizing center
GO:0010008 endosome membrane
GO:0012505 endomembrane system
GO:0016363 nuclear matrix
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001083314 NM_002768
HUGO
OMIM
CCDS CCDS45552
HPRD 01237
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca