Version 5.4
Homo sapiens Gene: LGR5
Summary
InnateDB Gene IDBG-47982.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGR5
Gene Name leucine-rich repeat containing G protein-coupled receptor 5
Synonyms FEX; GPR49; GPR67; GRP49; HG38
Species Homo sapiens
Ensembl Gene ENSG00000139292
Encoded Proteins
IDBP-47984
leucine-rich repeat containing G protein-coupled receptor 5
IDBP-603940
leucine-rich repeat containing G protein-coupled receptor 5
IDBP-603399
leucine-rich repeat containing G protein-coupled receptor 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:71439770-71586310
Strand Forward strand
Band q21.1
Transcripts
ENST00000266674 ENSP00000266674
ENST00000550851
ENST00000536515 ENSP00000443033
ENST00000540815 ENSP00000441035
ENST00000549015
ENST00000547310
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0048839 inner ear development
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0032588 trans-Golgi network membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020140
View Gene Order
ENSBTAG00000013256
Not yet available
Pathways
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200716
regulation of FZD by ubiquitination pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O75473
TrEMBL
UniProt Splice Variant
Entrez Gene 8549
UniGene Hs.604364 Hs.658889
RefSeq NM_003667 XM_005269204 NM_001277226 NM_001277227
HUGO HGNC:4504
OMIM 606667
CCDS CCDS9000 CCDS61194 CCDS61195
HPRD 05979
IMGT
EMBL AC078860 AC090116 AF061444 AF062006 BC096324 BC096325 BC096326 BC099650 FN820440
GenPept AAC28019 AAC77911 AAH96324 AAH96325 AAH96326 AAH99650 CBL95002
RNA Seq Atlas 8549

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca