Version 5.4
Homo sapiens Gene: TBC1D15
Summary
InnateDB Gene IDBG-48301.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBC1D15
Gene Name TBC1 domain family, member 15
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000121749
Encoded Proteins
IDBP-48303
TBC1 domain family, member 15
IDBP-586059
TBC1 domain family, member 15
IDBP-473852
TBC1 domain family, member 15
IDBP-476784
TBC1 domain family, member 15
IDBP-481452
TBC1 domain family, member 15
IDBP-479653
TBC1 domain family, member 15
IDBP-479948
TBC1 domain family, member 15
IDBP-479972
TBC1 domain family, member 15
IDBP-600470
TBC1 domain family, member 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may function as a regulator of intracellular trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:71839707-71927248
Strand Forward strand
Band q21.1
Transcripts
ENST00000319106 ENSP00000318262
ENST00000482439 ENSP00000449643
ENST00000491063 ENSP00000418091
ENST00000474468
ENST00000472611 ENSP00000419365
ENST00000498482 ENSP00000417308
ENST00000485960 ENSP00000420678
ENST00000468049 ENSP00000420190
ENST00000462788 ENSP00000418467
ENST00000460818
ENST00000483828
ENST00000479971
ENST00000550746 ENSP00000448182
ENST00000549402
ENST00000546932
ENST00000548679
ENST00000546450
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005097 Rab GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020130
View Gene Order
ENSBTAG00000012828
Not yet available
Cross-References
SwissProt
TrEMBL F8VV61
UniProt Splice Variant
Entrez Gene 64786
UniGene Hs.601024 Hs.613045
RefSeq NM_001146213 NM_001146214 NM_022771 XM_006719563 XM_006719564 XM_006719565 XM_006719566
HUGO HGNC:25694
OMIM 612662
CCDS CCDS31858 CCDS53814 CCDS55849
HPRD 15470
IMGT
EMBL AC089984 AC090109
GenPept
RNA Seq Atlas 64786

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca