Version 5.4
Homo sapiens Gene: CDC25B
Summary
InnateDB Gene IDBG-48355.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC25B
Gene Name cell division cycle 25 homolog B (S. pombe)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101224
Encoded Proteins
IDBP-48361
cell division cycle 25 homolog B (S. pombe)
IDBP-48363
cell division cycle 25 homolog B (S. pombe)
IDBP-48367
cell division cycle 25 homolog B (S. pombe)
IDBP-48369
cell division cycle 25 homolog B (S. pombe)
IDBP-364539
cell division cycle 25 homolog B (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:3786772-3806121
Strand Forward strand
Band p13
Transcripts
ENST00000245960 ENSP00000245960
ENST00000344256 ENSP00000339125
ENST00000340833 ENSP00000339170
ENST00000379598 ENSP00000368918
ENST00000439880 ENSP00000405972
ENST00000467519
ENST00000480816
ENST00000468979
ENST00000495915
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 50 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000087 mitotic M phase
GO:0000278 mitotic cell cycle
GO:0001556 oocyte maturation
GO:0006468 protein phosphorylation
GO:0006470 protein dephosphorylation
GO:0007067 mitotic nuclear division
GO:0007144 female meiosis I
GO:0008284 positive regulation of cell proliferation
GO:0032467 positive regulation of cytokinesis
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0045860 positive regulation of protein kinase activity
GO:0045931 positive regulation of mitotic cell cycle
Cellular Component
GO:0000922 spindle pole
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027330
View Gene Order
ENSBTAG00000008436
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_2101
Cyclin B2 mediated events pathway
REACT_899
S Phase pathway
REACT_115566
Cell Cycle pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
hsa04110
Cell cycle pathway
hsa04010
MAPK signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
INOH
PID NCI
aurora_a_pathway
Aurora A signaling
foxm1pathway
FOXM1 transcription factor network
p38_mk2pathway
p38 signaling mediated by MAPKAP kinases
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.153752
RefSeq NM_001287516 NM_001287517 NM_001287518 NM_001287519 NM_001287520 NM_001287522 NM_004358 NM_021872 NM_021873
HUGO
OMIM
CCDS CCDS13065 CCDS13066 CCDS13067 CCDS74700 CCDS74701
HPRD 00307
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca