Version 5.4
Homo sapiens Gene: PFDN1
Summary
InnateDB Gene IDBG-48422.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFDN1
Gene Name prefoldin subunit 1
Synonyms PDF; PFD1
Species Homo sapiens
Ensembl Gene ENSG00000113068
Encoded Proteins
IDBP-48424
prefoldin subunit 1
IDBP-485453
prefoldin subunit 1
IDBP-476062
prefoldin subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:140245039-140303121
Strand Reverse strand
Band q31.3
Transcripts
ENST00000261813 ENSP00000261813
ENST00000514611
ENST00000510217 ENSP00000426383
ENST00000512707
ENST00000524074 ENSP00000428707
ENST00000512925
ENST00000507185
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 116 experimentally validated interaction(s) in this database.
Experimentally validated
Total 116 [view]
Protein-Protein 116 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0051082 unfolded protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006457 protein folding
GO:0007049 cell cycle
GO:0021537 telencephalon development
GO:0021549 cerebellum development
GO:0030036 actin cytoskeleton organization
GO:0042113 B cell activation
GO:0044267 cellular protein metabolic process
GO:0051084 'de novo' posttranslational protein folding
Cellular Component
GO:0016272 prefoldin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024346
View Gene Order
ENSBTAG00000016596
Not yet available
Pathways
NETPATH
REACTOME
REACT_16936
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_16952
Protein folding pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
REACT_17029
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_002622
HUGO
OMIM
CCDS CCDS4222
HPRD 05357
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca