Version 5.4
Homo sapiens Gene: CBLB
Summary
InnateDB Gene IDBG-48442.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CBLB
Gene Name Cbl proto-oncogene, E3 ubiquitin protein ligase B
Synonyms Cbl-b; RNF56
Species Homo sapiens
Ensembl Gene ENSG00000114423
Encoded Proteins
IDBP-48444
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
IDBP-242410
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
IDBP-295270
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
IDBP-295264
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
IDBP-295266
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
IDBP-382029
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
IDBP-382031
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
IDBP-382033
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:105655461-105869552
Strand Reverse strand
Band q13.11
Transcripts
ENST00000264122 ENSP00000264122
ENST00000394030 ENSP00000377598
ENST00000407712 ENSP00000384170
ENST00000405772 ENSP00000384938
ENST00000403724 ENSP00000384816
ENST00000443752 ENSP00000393906
ENST00000447441 ENSP00000400949
ENST00000438603 ENSP00000409750
ENST00000476370
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0002669 positive regulation of T cell anergy
GO:0006607 NLS-bearing protein import into nucleus
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0016567 protein ubiquitination
GO:0023051 regulation of signaling
GO:0035556 intracellular signal transduction
GO:0042110 T cell activation
GO:0045732 positive regulation of protein catabolic process
GO:0046642 negative regulation of alpha-beta T cell proliferation
GO:0050860 negative regulation of T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022637
View Gene Order
ENSBTAG00000013057
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_19
IL-7 pathway
NetPath_21
RANKL pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
KEGG
hsa04012
ErbB signaling pathway pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04910
Insulin signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05220
Chronic myeloid leukemia pathway
hsa04144
Endocytosis pathway
hsa05200
Pathways in cancer pathway
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
cd40_pathway
CD40/CD40L signaling
erbb1_internalization_pathway
Internalization of ErbB1
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.430589 Hs.622985
RefSeq NM_170662 XM_005247852 XM_005247853 XM_006713796
HUGO
OMIM
CCDS CCDS2948
HPRD 05136
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca