Homo sapiens Gene: DEPDC5 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-4850.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | DEPDC5 | ||||||||||||||||||
Gene Name | DEP domain containing 5 | ||||||||||||||||||
Synonyms | DEP.5; FFEVF | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000100150 | ||||||||||||||||||
Encoded Proteins |
DEP domain containing 5
DEP domain containing 5
DEP domain containing 5
DEP domain containing 5
DEP domain containing 5
DEP domain containing 5
DEP domain containing 5
DEP domain containing 5
DEP domain containing 5
DEP domain containing 5
DEP domain containing 5
DEP domain containing 5
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 22:31753951-31907034 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q12.2 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | |||||||||||||||||||
RefSeq | NM_001007188 NM_001136029 NM_001242896 NM_001242897 NM_014662 XM_005261862 XM_005261863 XM_005261864 XM_005261866 XM_006724385 XM_006724386 XM_006724387 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS43006 CCDS43007 CCDS46692 CCDS56229 CCDS74849 | ||||||||||||||||||
HPRD | 16795 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||