Version 5.4
Mus musculus Gene: Bloc1s1
Summary
InnateDB Gene IDBG-486103.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bloc1s1
Gene Name biogenesis of lysosome-related organelles complex-1, subunit 1
Synonyms AI839753; BLOS1; Gcn5l1
Species Mus musculus
Ensembl Gene ENSMUSG00000090247
Encoded Proteins
IDBP-198655
biogenesis of lysosome-related organelles complex-1, subunit 1
IDBP-542487
biogenesis of lysosome-related organelles complex-1, subunit 1
IDBP-538982
biogenesis of lysosome-related organelles complex-1, subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135441:
BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004 [PubMed 15102850]).[supplied by OMIM, Mar 2008]
BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell\'Angelica, 2004 [PubMed 15102850]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:128917882-128924035
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000026405 ENSMUSP00000026405
ENSMUST00000153731 ENSMUSP00000117408
ENSMUST00000131271 ENSMUSP00000114321
ENSMUST00000141320
ENSMUST00000143628
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008089 anterograde axon cargo transport
GO:0009060 aerobic respiration
GO:0018394 peptidyl-lysine acetylation
GO:0031175 neuron projection development
GO:0048490 anterograde synaptic vesicle transport
Cellular Component
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0031083 BLOC-1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000135441
View Gene Order
ENSBTAG00000011918
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_231722
Lysosome Vesicle Biogenesis pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
REACTOME
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O55102
TrEMBL D3YVM8 D3Z4L7
UniProt Splice Variant
Entrez Gene 666114
UniGene
RefSeq NM_015740 XM_006513229 XM_006526401 XM_006543415
OMIM
CCDS CCDS24299
HPRD
IMGT
MGI ID MGI:1195276
MGI Symbol Bloc1s1
EMBL AC122380 AK003035 BC034662 Y13778 Y13779 Y13780 Y13781
GenPept AAH34662 BAB22523 CAA74108
RNA Seq Atlas 14533 666114

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca