Homo sapiens Gene: MRPL16
Summary
InnateDB Gene IDBG-48642.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL16
Gene Name mitochondrial ribosomal protein L16
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166902
Encoded Proteins
mitochondrial ribosomal protein L16
mitochondrial ribosomal protein L16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:59806135-59810872
Strand Reverse strand
Band q12.1
Transcripts
ENST00000300151 ENSP00000300151
ENST00000534340 ENSP00000436592
ENST00000525470
ENST00000531802
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005739 mitochondrion
GO:0005840 ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9NX20
TrEMBL E9PI14
UniProt Splice Variant
Entrez Gene 54948
UniGene
RefSeq NM_017840
HUGO HGNC:14476
OMIM 611829
CCDS CCDS7976
HPRD
IMGT
EMBL AB049642 AF183428 AF275806 AK000491 AP000640 BC001040 BC019269 CR457117
GenPept AAG09697 AAG23818 AAH01040 AAH19269 BAA91202 BAB40847 CAG33398
RNA Seq Atlas 54948