InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HAAO

Summary

InnateDB Gene

IDBG-48645.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HAAO

Gene Name

3-hydroxyanthranilate 3,4-dioxygenase

Synonyms

3-HAO; HAO

Species

Homo sapiens

Ensembl Gene

ENSG00000162882

Encoded Proteins

IDBP-48647

3-hydroxyanthranilate 3,4-dioxygenase

IDBP-373888

3-hydroxyanthranilate 3,4-dioxygenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:42767089-42792593

Strand

Reverse strand

Band

p21

Transcripts

ENST00000294973	ENSP00000294973
ENST00000406007
ENST00000402698
ENST00000406924
ENST00000402268
ENST00000404451
ENST00000431905	ENSP00000412601

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000334	3-hydroxyanthranilate 3,4-dioxygenase activity
GO:0005506	iron ion binding
GO:0008198	ferrous iron binding
GO:0009055	electron carrier activity
GO:0019825	oxygen binding
GO:0046872	metal ion binding

Biological Process

GO:0006569	tryptophan catabolic process
GO:0010043	response to zinc ion
GO:0019805	quinolinate biosynthetic process
GO:0034354	'de novo' NAD biosynthetic process from tryptophan
GO:0034641	cellular nitrogen compound metabolic process
GO:0043420	anthranilate metabolic process
GO:0044281	small molecule metabolic process
GO:0046686	response to cadmium ion
GO:0046874	quinolinate metabolic process
GO:0055114	oxidation-reduction process
GO:0070050	neuron cellular homeostasis

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031966	mitochondrial membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000000673

View Gene Order

ENSBTAG00000004674

Not yet available

Pathways

NETPATH

REACTOME

REACT_916

Tryptophan catabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00380

Tryptophan metabolism pathway

INOH

INOH website

Tryptophan degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.368805

RefSeq

NM_012205

HUGO

OMIM

CCDS

CCDS33187

HPRD

05158

IMGT

EMBL

GenPept

RNA Seq Atlas