InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gm20431

Summary

InnateDB Gene

IDBG-486455.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gm20431

Gene Name

predicted gene 20431

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000089739

Encoded Proteins

IDBP-538416

transmembrane protein 189

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000240849:
The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010] Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012] Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:167607850-167661496

Strand

Reverse strand

Band

Transcripts

ENSMUST00000125544

ENSMUSP00000118416

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0008152

metabolic process

Cellular Component

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000240849

View Gene Order

Cross-References

SwissProt

TrEMBL

E9PY39

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

OMIM

CCDS

HPRD

IMGT

MGI ID

MGI:5141896

MGI Symbol

Gm20431

EMBL

AL589870 CR626861

GenPept

RNA Seq Atlas