Version 5.4
Homo sapiens Gene: GLDC
Summary
InnateDB Gene IDBG-48712.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLDC
Gene Name glycine dehydrogenase (decarboxylating)
Synonyms GCE; GCSP; HYGN1
Species Homo sapiens
Ensembl Gene ENSG00000178445
Encoded Proteins
IDBP-48716
glycine dehydrogenase (decarboxylating)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:6532464-6645650
Strand Reverse strand
Band p24.1
Transcripts
ENST00000321612 ENSP00000370737
ENST00000477960
ENST00000467946
ENST00000460457
ENST00000463305
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004375 glycine dehydrogenase (decarboxylating) activity
GO:0009055 electron carrier activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006520 cellular amino acid metabolic process
GO:0006544 glycine metabolic process
GO:0006546 glycine catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024827
View Gene Order
ENSBTAG00000025903
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00260
Glycine, serine and threonine metabolism pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.584238 Hs.603778
RefSeq NM_000170
HUGO
OMIM
CCDS CCDS34987
HPRD 01996
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca