InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD47

Summary

InnateDB Gene

IDBG-48744.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD47

Gene Name

CD47 molecule

Synonyms

IAP; MER6; OA3

Species

Homo sapiens

Ensembl Gene

ENSG00000196776

Encoded Proteins

IDBP-48746

CD47 molecule

IDBP-48748

CD47 molecule

IDBP-233487

CD47 molecule

IDBP-481421

CD47 molecule

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26010544

[Mus musculus] Cd47 plays a protective role against disseminated candidiasis and alters pro-inflammatory and immunosuppressive pathways known to regulate innate and T cell immunity.

PMID 27194758

[Mus musculus] Cd47 plays a role as a negative regulator in inducing protective immune responses to influenza vaccination.

Entrez Gene

Summary

This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:108043298-108091025

Strand

Reverse strand

Band

q13.12

Transcripts

ENST00000355354	ENSP00000347512
ENST00000361309	ENSP00000355361
ENST00000398258	ENSP00000381309
ENST00000471694
ENST00000517766	ENSP00000430843

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0070053	thrombospondin receptor activity

Biological Process

GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007596	blood coagulation
GO:0008228	opsonization
GO:0008284	positive regulation of cell proliferation
GO:0009617	response to bacterium
GO:0022409	positive regulation of cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0050729	positive regulation of inflammatory response
GO:0050766	positive regulation of phagocytosis
GO:0050870	positive regulation of T cell activation
GO:0050900	leukocyte migration

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000055447

View Gene Order

ENSBTAG00000003585

Not yet available

Pathways

NETPATH

REACTOME

REACT_12051

Cell surface interactions at the vascular wall pathway

REACT_13552

Integrin cell surface interactions pathway

REACT_23916

Signal regulatory protein (SIRP) family interactions pathway

REACT_111155

Cell-Cell communication pathway

REACT_118779

Extracellular matrix organization pathway

REACT_604

Hemostasis pathway

KEGG

hsa04512

ECM-receptor interaction pathway

INOH

PID NCI

integrin3_pathway

Beta3 integrin cell surface interactions

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.674188 Hs.702403 Hs.713993

RefSeq

NM_001777 NM_198793

HUGO

OMIM

CCDS

CCDS43125 CCDS43126

HPRD

03017

IMGT

EMBL

GenPept

RNA Seq Atlas