Version 5.4
Homo sapiens Gene: UCN3
Summary
InnateDB Gene IDBG-48764.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UCN3
Gene Name urocortin 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000178473
Encoded Proteins
IDBP-48766
urocortin 3 (stresscopin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:5365009-5374692
Strand Forward strand
Band p15.1
Transcripts
ENST00000380433 ENSP00000369798
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0051431 corticotropin-releasing hormone receptor 2 binding
Biological Process
GO:0006950 response to stress
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007586 digestion
GO:0009749 response to glucose
GO:0031669 cellular response to nutrient levels
GO:0032024 positive regulation of insulin secretion
GO:0035902 response to immobilization stress
GO:0042594 response to starvation
GO:0045838 positive regulation of membrane potential
GO:0051412 response to corticosterone
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005615 extracellular space
GO:0030424 axon
GO:0043005 neuron projection
GO:0043196 varicosity
GO:0043679 axon terminus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044988
View Gene Order
ENSBTAG00000035696
Not yet available
Cross-References
SwissProt Q969E3
TrEMBL
UniProt Splice Variant
Entrez Gene 114131
UniGene Hs.511775
RefSeq NM_053049
HUGO HGNC:17781
OMIM 605901
CCDS CCDS7065
HPRD
IMGT
EMBL AF361943 AL683826 AY026949 BC069530 BC100867 BC100868 BC100869 BC100870
GenPept AAH69530 AAI00868 AAI00869 AAI00870 AAI00871 AAK11729 AAK67317 CAI23624
RNA Seq Atlas 114131

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca