Version 5.4
Homo sapiens Gene: SIRT2
Summary
InnateDB Gene IDBG-49708.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIRT2
Gene Name sirtuin 2
Synonyms SIR2; SIR2L; SIR2L2
Species Homo sapiens
Ensembl Gene ENSG00000068903
Encoded Proteins
IDBP-379601
sirtuin 2
IDBP-49710
sirtuin 2
IDBP-49712
sirtuin 2
IDBP-246374
sirtuin 2
IDBP-295050
sirtuin 2
IDBP-379594
sirtuin 2
IDBP-379595
sirtuin 2
IDBP-379598
sirtuin 2
IDBP-379602
sirtuin 2
IDBP-379603
sirtuin 2
IDBP-379604
sirtuin 2
IDBP-379607
sirtuin 2
IDBP-806819
sirtuin 2
IDBP-806821
sirtuin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38878555-38899862
Strand Reverse strand
Band q13.2
Transcripts
ENST00000381766 ENSP00000401203
ENST00000249396 ENSP00000249396
ENST00000358931 ENSP00000351809
ENST00000392081 ENSP00000375931
ENST00000407552 ENSP00000385146
ENST00000414941 ENSP00000404309
ENST00000420440 ENSP00000400338
ENST00000443898 ENSP00000411393
ENST00000451193 ENSP00000407272
ENST00000423526 ENSP00000409690
ENST00000437828 ENSP00000397022
ENST00000447739 ENSP00000408023
ENST00000462654
ENST00000479290
ENST00000496069
ENST00000491960
ENST00000476771
ENST00000481381
ENST00000620437 ENSP00000484934
ENST00000613542 ENSP00000481932
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 105 [view]
Protein-Protein 34 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 70 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017136 NAD-dependent histone deacetylase activity
GO:0033558 protein deacetylase activity
GO:0034979 NAD-dependent protein deacetylase activity
GO:0035035 histone acetyltransferase binding
GO:0042826 histone deacetylase binding
GO:0042903 tubulin deacetylase activity
GO:0043130 ubiquitin binding
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048487 beta-tubulin binding
GO:0051287 NAD binding
GO:0070403 NAD+ binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000183 chromatin silencing at rDNA
GO:0006342 chromatin silencing
GO:0006348 chromatin silencing at telomere
GO:0006351 transcription, DNA-templated
GO:0006471 protein ADP-ribosylation
GO:0006476 protein deacetylation
GO:0006914 autophagy
GO:0007067 mitotic nuclear division
GO:0007096 regulation of exit from mitosis
GO:0007126 meiotic nuclear division
GO:0008219 cell death
GO:0008285 negative regulation of cell proliferation
GO:0010507 negative regulation of autophagy
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016458 gene silencing
GO:0016575 histone deacetylation
GO:0021762 substantia nigra development
GO:0022011 myelination in peripheral nervous system
GO:0031641 regulation of myelination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034599 cellular response to oxidative stress
GO:0034983 peptidyl-lysine deacetylation
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0042177 negative regulation of protein catabolic process
GO:0042325 regulation of phosphorylation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043388 positive regulation of DNA binding
GO:0043491 protein kinase B signaling
GO:0044242 cellular lipid catabolic process
GO:0045087 innate immune response
GO:0045599 negative regulation of fat cell differentiation
GO:0045836 positive regulation of meiosis
GO:0045843 negative regulation of striated muscle tissue development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0051726 regulation of cell cycle
GO:0051775 response to redox state
GO:0051781 positive regulation of cell division
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore
GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061433 cellular response to caloric restriction
GO:0070446 negative regulation of oligodendrocyte progenitor proliferation
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0071219 cellular response to molecule of bacterial origin
GO:0071456 cellular response to hypoxia
GO:0071872 cellular response to epinephrine stimulus
GO:0090042 tubulin deacetylation
GO:1900119 positive regulation of execution phase of apoptosis
GO:1900195 positive regulation of oocyte maturation
GO:1900425 negative regulation of defense response to bacterium
GO:1901026 ripoptosome assembly involved in necroptotic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
Cellular Component
GO:0005634 nucleus
GO:0005677 chromatin silencing complex
GO:0005694 chromosome
GO:0005720 nuclear heterochromatin
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0030426 growth cone
GO:0030496 midbody
GO:0033010 paranodal junction
GO:0033270 paranode region of axon
GO:0043204 perikaryon
GO:0043209 myelin sheath
GO:0043219 lateral loop
GO:0043220 Schmidt-Lanterman incisure
GO:0044224 juxtaparanode region of axon
GO:0048471 perinuclear region of cytoplasm
GO:0072686 mitotic spindle
GO:0072687 meiotic spindle
GO:0097386 glial cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015149
View Gene Order
ENSBTAG00000001776
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.466693 Hs.609292
RefSeq NM_001193286 NM_012237 NM_030593 XM_006723111
HUGO
OMIM
CCDS CCDS12523 CCDS46069 CCDS74361
HPRD 10377
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca