Version 5.4
Homo sapiens Gene: TNFSF13B
Summary
InnateDB Gene IDBG-49841.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFSF13B
Gene Name tumor necrosis factor (ligand) superfamily, member 13b
Synonyms BAFF; BLYS; CD257; DTL; TALL-1; TALL1; THANK; TNFSF20; ZTNF4
Species Homo sapiens
Ensembl Gene ENSG00000102524
Encoded Proteins
IDBP-49843
tumor necrosis factor (ligand) superfamily, member 13b
IDBP-373344
tumor necrosis factor (ligand) superfamily, member 13b
IDBP-593171
tumor necrosis factor (ligand) superfamily, member 13b
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:108251240-108308484
Strand Forward strand
Band q33.3
Transcripts
ENST00000375887 ENSP00000365048
ENST00000430559 ENSP00000389540
ENST00000486502
ENST00000479435
ENST00000493765
ENST00000542136 ENSP00000445334
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 13 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0001782 B cell homeostasis
GO:0002636 positive regulation of germinal center formation
GO:0006955 immune response
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0030890 positive regulation of B cell proliferation
GO:0031295 T cell costimulation
GO:0031296 B cell costimulation
GO:0042102 positive regulation of T cell proliferation
GO:0048305 immunoglobulin secretion
GO:0050776 regulation of immune response
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031497
View Gene Order
ENSBTAG00000011563
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.525157
RefSeq NM_001145645 NM_006573
HUGO
OMIM
CCDS CCDS45067 CCDS9509
HPRD 04914
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca