Version 5.4
Homo sapiens Gene: PCDHB4
Summary
InnateDB Gene IDBG-49897.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDHB4
Gene Name protocadherin beta 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000081818
Encoded Proteins
IDBP-49899
protocadherin beta 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:141121799-141125623
Strand Forward strand
Band q31.3
Transcripts
ENST00000194152 ENSP00000194152
ENST00000623478
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0007268 synaptic transmission
GO:0007399 nervous system development
GO:0007416 synapse assembly
GO:0016339 calcium-dependent cell-cell adhesion
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045111 intermediate filament cytoskeleton
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9Y5E5
TrEMBL
UniProt Splice Variant
Entrez Gene 56131
UniGene Hs.283661 Hs.591250
RefSeq NM_018938
HUGO HGNC:8689
OMIM 606330
CCDS CCDS4246
HPRD
IMGT
EMBL AF152497 AF217754 BC098139 BC098346
GenPept AAD43758 AAH98139 AAH98346 AAK51621
RNA Seq Atlas 56131

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca