Homo sapiens Gene: NTS
Summary
InnateDB Gene IDBG-50023.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NTS
Gene Name neurotensin
Synonyms NMN-125; NN; NT; NT/N; NTS1
Species Homo sapiens
Ensembl Gene ENSG00000133636
Encoded Proteins
neurotensin
neurotensin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:85874295-85882992
Strand Forward strand
Band q21.31
Transcripts
ENST00000256010 ENSP00000256010
ENST00000551529 ENSP00000448328
ENST00000550879
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0050880 regulation of blood vessel size
Cellular Component
GO:0005576 extracellular region
GO:0030133 transport vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
INOH
PID NCI
AP-1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_006183
HUGO
OMIM
CCDS CCDS9029
HPRD 08878
IMGT
EMBL
GenPept
RNA Seq Atlas