Version 5.4
Homo sapiens Gene: PCDHB10
Summary
InnateDB Gene IDBG-50074.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDHB10
Gene Name protocadherin beta 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120324
Encoded Proteins
IDBP-50076
protocadherin beta 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:141187319-141195642
Strand Forward strand
Band q31.3
Transcripts
ENST00000239446 ENSP00000239446
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0007268 synaptic transmission
GO:0007416 synapse assembly
GO:0016339 calcium-dependent cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000048347
View Gene Order
Cross-References
SwissProt Q9UN67
TrEMBL O95883
UniProt Splice Variant
Entrez Gene 56126
UniGene Hs.657953
RefSeq NM_018930
HUGO HGNC:8681
OMIM 606336
CCDS CCDS4252
HPRD
IMGT
EMBL AF131761 AF152489 AF217748 AY358720 BC031837
GenPept AAD20038 AAD43750 AAH31837 AAK51616 AAQ89082
RNA Seq Atlas 56126

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca