Version 5.4
Homo sapiens Gene: SDHAF2
Summary
InnateDB Gene IDBG-50166.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SDHAF2
Gene Name succinate dehydrogenase complex assembly factor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167985
Encoded Proteins
IDBP-50168
succinate dehydrogenase complex assembly factor 2
IDBP-68306
succinate dehydrogenase complex assembly factor 2
IDBP-591874
succinate dehydrogenase complex assembly factor 2
IDBP-718826
IDBP-719243
IDBP-718816
IDBP-718554
IDBP-589209
succinate dehydrogenase complex assembly factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:61430042-61447529
Strand Forward strand
Band q12.2
Transcripts
ENST00000301761 ENSP00000301761
ENST00000359614 ENSP00000352630
ENST00000542794 ENSP00000439983
ENST00000542074 ENSP00000469670
ENST00000534878 ENSP00000471030
ENST00000537782 ENSP00000469951
ENST00000536250 ENSP00000471120
ENST00000543265 ENSP00000443660
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006121 mitochondrial electron transport, succinate to ubiquinone
GO:0006470 protein dephosphorylation
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0018293 protein-FAD linkage
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024668
View Gene Order
ENSBTAG00000015266
Not yet available
Cross-References
SwissProt
TrEMBL M0QY91
UniProt Splice Variant
Entrez Gene 54949
UniGene Hs.609629
RefSeq NM_017841
HUGO HGNC:26034
OMIM 613019
CCDS CCDS8007
HPRD 07915
IMGT
EMBL AP003108
GenPept
RNA Seq Atlas 54949

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca