InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: INCENP

Summary

InnateDB Gene

IDBG-50806.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INCENP

Gene Name

inner centromere protein antigens 135/155kDa

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000149503

Encoded Proteins

IDBP-50808

inner centromere protein antigens 135/155kDa

IDBP-240810

inner centromere protein antigens 135/155kDa

IDBP-587862

inner centromere protein antigens 135/155kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and \'passenger,\' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term \'passenger proteins\' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:62123973-62153163

Strand

Forward strand

Band

q12.3

Transcripts

ENST00000278849	ENSP00000278849
ENST00000394818	ENSP00000378295
ENST00000533896	ENSP00000433100
ENST00000528037
ENST00000528375
ENST00000531099

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	35 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0000910	cytokinesis
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000795	synaptonemal complex
GO:0000800	lateral element
GO:0000801	central element
GO:0005721	centromeric heterochromatin
GO:0005819	spindle
GO:0005829	cytosol
GO:0005874	microtubule
GO:0010369	chromocenter
GO:0030496	midbody
GO:0043234	protein complex