InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: B3GAT3

Summary

InnateDB Gene

IDBG-51329.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B3GAT3

Gene Name

beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000149541

Encoded Proteins

IDBP-51331

beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)

IDBP-592841

beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)

IDBP-583533

beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)

IDBP-596552

beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)

IDBP-586536

beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:62615296-62622175

Strand

Reverse strand

Band

q12.3

Transcripts

ENST00000265471	ENSP00000265471
ENST00000531383	ENSP00000431359
ENST00000532585	ENSP00000432604
ENST00000534026	ENSP00000432474
ENST00000533303
ENST00000534715	ENSP00000432854

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
GO:0015020	glucuronosyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006486	protein glycosylation
GO:0008152	metabolic process
GO:0015012	heparan sulfate proteoglycan biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0044281	small molecule metabolic process
GO:0050650	chondroitin sulfate proteoglycan biosynthetic process
GO:0050651	dermatan sulfate proteoglycan biosynthetic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0005801	cis-Golgi network
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome