Version 5.4
Homo sapiens Gene: HAL
Summary
InnateDB Gene IDBG-51903.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HAL
Gene Name histidine ammonia-lyase
Synonyms HIS; HSTD
Species Homo sapiens
Ensembl Gene ENSG00000084110
Encoded Proteins
IDBP-51905
histidine ammonia-lyase
IDBP-599829
histidine ammonia-lyase
IDBP-589414
histidine ammonia-lyase
IDBP-591075
histidine ammonia-lyase
IDBP-588868
histidine ammonia-lyase
IDBP-600904
histidine ammonia-lyase
IDBP-587023
histidine ammonia-lyase
IDBP-595672
histidine ammonia-lyase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:95972662-95996365
Strand Reverse strand
Band q23.1
Transcripts
ENST00000261208 ENSP00000261208
ENST00000544080 ENSP00000439385
ENST00000538703 ENSP00000440861
ENST00000546999 ENSP00000447675
ENST00000548808 ENSP00000446678
ENST00000548636
ENST00000552509 ENSP00000450372
ENST00000551562
ENST00000549376
ENST00000546579 ENSP00000447543
ENST00000541929 ENSP00000446364
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004397 histidine ammonia-lyase activity
GO:0016841 ammonia-lyase activity
Biological Process
GO:0006548 histidine catabolic process
GO:0009058 biosynthetic process
GO:0019556 histidine catabolic process to glutamate and formamide
GO:0019557 histidine catabolic process to glutamate and formate
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020017
View Gene Order
ENSBTAG00000016276
Not yet available
Pathways
NETPATH
REACTOME
REACT_1249
Histidine catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00340
Histidine metabolism pathway
INOH
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.190783 Hs.742210
RefSeq NM_001258333 NM_001258334 NM_002108
HUGO
OMIM
CCDS CCDS58264 CCDS58265 CCDS9058
HPRD 07187
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca