Version 5.4
Homo sapiens Gene: KIN
Summary
InnateDB Gene IDBG-51974.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIN
Gene Name KIN, antigenic determinant of recA protein homolog (mouse)
Synonyms BTCD; KIN17; Rts2
Species Homo sapiens
Ensembl Gene ENSG00000151657
Encoded Proteins
IDBP-51976
KIN, antigenic determinant of recA protein homolog (mouse)
IDBP-806621
Kin17 DNA and RNA binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:7750962-7787981
Strand Reverse strand
Band p14
Transcripts
ENST00000379562 ENSP00000368881
ENST00000498098 ENSP00000473950
ENST00000463666
ENST00000471320
ENST00000460089
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006397 mRNA processing
GO:0006974 cellular response to DNA damage stimulus
GO:0016032 viral process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037262
View Gene Order
ENSBTAG00000013925
Not yet available
Cross-References
SwissProt
TrEMBL S4R357
UniProt Splice Variant
Entrez Gene 22944
UniGene
RefSeq NM_012311 XM_006717434
HUGO HGNC:6327
OMIM 601720
CCDS CCDS7080
HPRD
IMGT
EMBL AL158044
GenPept
RNA Seq Atlas 22944

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca