Version 5.4
Homo sapiens Gene: PRDX4
Summary
InnateDB Gene IDBG-52043.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRDX4
Gene Name peroxiredoxin 4
Synonyms AOE37-2; AOE372; HEL-S-97n; PRX-4
Species Homo sapiens
Ensembl Gene ENSG00000123131
Encoded Proteins
IDBP-52045
peroxiredoxin 4
IDBP-52047
peroxiredoxin 4
IDBP-52049
peroxiredoxin 4
IDBP-365415
peroxiredoxin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:23664262-23686399
Strand Forward strand
Band p22.11
Transcripts
ENST00000379349 ENSP00000368654
ENST00000379341 ENSP00000368646
ENST00000379331 ENSP00000368635
ENST00000439422 ENSP00000413736
ENST00000495599
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
Experimentally validated
Total 65 [view]
Protein-Protein 64 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008379 thioredoxin peroxidase activity
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
GO:0051920 peroxiredoxin activity
Biological Process
GO:0007252 I-kappaB phosphorylation
GO:0007283 spermatogenesis
GO:0008584 male gonad development
GO:0019471 4-hydroxyproline metabolic process
GO:0022417 protein maturation by protein folding
GO:0030198 extracellular matrix organization
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
GO:0072593 reactive oxygen species metabolic process
GO:2000255 negative regulation of male germ cell proliferation
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005790 smooth endoplasmic reticulum
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025289
View Gene Order
ENSBTAG00000006165
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_006406 XM_005274438
HUGO
OMIM
CCDS CCDS14206
HPRD 05935
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca