Version 5.4
| Homo sapiens Gene: PPP2R2B | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-52116.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PPP2R2B | ||||||||||||||||||
| Gene Name | protein phosphatase 2, regulatory subunit B, beta | ||||||||||||||||||
| Synonyms | B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B; PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B; PR55-BETA; PR55BETA; SCA12 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000156475 | ||||||||||||||||||
| Encoded Proteins |
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
protein phosphatase 2, regulatory subunit B, beta
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. [provided by RefSeq, Jul 2008] The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5\' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 5:146581146-147084784 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q32 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG |
Tight junction pathway
Chagas disease (American trypanosomiasis) pathway
mRNA surveillance pathway pathway
Hepatitis C pathway
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| INOH |
Insulin receptor signaling pathway
GPCR Dopamine D1like receptor signaling pathway pathway
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| PID NCI |
ATR signaling pathway
PDGFR-beta signaling pathway
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.655213 Hs.739387 | ||||||||||||||||||
| RefSeq | NM_001271899 NM_001271900 NM_001271948 NM_181674 NM_181675 NM_181676 NM_181677 NM_181678 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS4283 CCDS4284 CCDS43380 CCDS64282 | ||||||||||||||||||
| HPRD | 05059 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||