Version 5.4
Homo sapiens Gene: GEMIN2
Summary
InnateDB Gene IDBG-5223.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GEMIN2
Gene Name gem (nuclear organelle) associated protein 2
Synonyms SIP1; SIP1-delta
Species Homo sapiens
Ensembl Gene ENSG00000092208
Encoded Proteins
IDBP-5225
gem (nuclear organelle) associated protein 2
IDBP-5227
gem (nuclear organelle) associated protein 2
IDBP-237889
gem (nuclear organelle) associated protein 2
IDBP-366584
gem (nuclear organelle) associated protein 2
IDBP-591076
gem (nuclear organelle) associated protein 2
IDBP-595198
gem (nuclear organelle) associated protein 2
IDBP-593446
gem (nuclear organelle) associated protein 2
IDBP-588138
gem (nuclear organelle) associated protein 2
IDBP-808046
gem (nuclear organelle) associated protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:39114223-39136973
Strand Forward strand
Band q21.1
Transcripts
ENST00000308317 ENSP00000308533
ENST00000250379 ENSP00000250379
ENST00000396249 ENSP00000379548
ENST00000412033 ENSP00000416827
ENST00000525153 ENSP00000436854
ENST00000531684 ENSP00000431500
ENST00000534684 ENSP00000436065
ENST00000525430
ENST00000527381 ENSP00000434048
ENST00000524980
ENST00000529365
ENST00000524781 ENSP00000474979
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 32 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000387 spliceosomal snRNP assembly
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0034660 ncRNA metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032797 SMN complex
GO:0034719 SMN-Sm protein complex
GO:0097504 Gemini of coiled bodies
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000060121
View Gene Order
ENSBTAG00000020930
Not yet available
Pathways
NETPATH
REACTOME
REACT_11066
snRNP Assembly pathway
REACT_11052
Metabolism of non-coding RNA pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.652307 Hs.722259
RefSeq NM_001009182 NM_001009183 NM_003616
HUGO
OMIM
CCDS CCDS32068 CCDS41946 CCDS9669
HPRD 03999
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca