InnateDB Gene
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IDBG-52476.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CSTA
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Gene Name
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cystatin A (stefin A)
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Synonyms
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AREI; STF1; STFA
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Species
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Homo sapiens
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Ensembl Gene
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ENSG00000121552
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Encoded Proteins
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Protein Structure
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Useful resources
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Stemformatics
EHFPI
ImmGen
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Summary |
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008]
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Type |
Protein coding
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Genomic Location
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Chromosome 3:122325244-122341972
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Strand
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Forward strand
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Band
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q21.1
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Transcripts
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Number of Interactions
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This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
23
[view]
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Protein-Protein |
23
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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No orthologs found for this gene |
SwissProt
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TrEMBL
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UniProt Splice Variant
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Entrez Gene
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UniGene
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RefSeq
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NM_005213
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HUGO
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OMIM
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CCDS
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CCDS3011
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HPRD |
01697
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IMGT
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EMBL
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GenPept
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RNA Seq Atlas
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