Version 5.4
Homo sapiens Gene: RARRES3
Summary
InnateDB Gene IDBG-52511.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RARRES3
Gene Name retinoic acid receptor responder (tazarotene induced) 3
Synonyms HRASLS4; HRSL4; PLA1/2-3; RIG1; TIG3
Species Homo sapiens
Ensembl Gene ENSG00000133321
Encoded Proteins
IDBP-52513
retinoic acid receptor responder (tazarotene induced) 3
IDBP-52515
retinoic acid receptor responder (tazarotene induced) 3
IDBP-376733
retinoic acid receptor responder (tazarotene induced) 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:63536809-63546462
Strand Forward strand
Band q12.3
Transcripts
ENST00000255688 ENSP00000255688
ENST00000354445 ENSP00000346431
ENST00000439013 ENSP00000402943
ENST00000537871
ENST00000544107
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005515 protein binding
Biological Process
GO:0006644 phospholipid metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0016042 lipid catabolic process
Cellular Component
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004585
HUGO
OMIM
CCDS CCDS41662
HPRD 05479
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca