Version 5.4
Homo sapiens Gene: CYP2S1
Summary
InnateDB Gene IDBG-52589.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP2S1
Gene Name cytochrome P450, family 2, subfamily S, polypeptide 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167600
Encoded Proteins
IDBP-52591
cytochrome P450, family 2, subfamily S, polypeptide 1
IDBP-765076
IDBP-765770
IDBP-763932
IDBP-761420
IDBP-760315
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:41193049-41207539
Strand Forward strand
Band q13.2
Transcripts
ENST00000310054 ENSP00000308032
ENST00000593890 ENSP00000469850
ENST00000597754 ENSP00000471637
ENST00000600561 ENSP00000471016
ENST00000595590 ENSP00000469593
ENST00000593545 ENSP00000472555
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040703
View Gene Order
ENSBTAG00000018240
Not yet available
Pathways
NETPATH
REACTOME
REACT_13425
Miscellaneous substrates pathway
REACT_13797
CYP2E1 reactions pathway
REACT_13543
Xenobiotics pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa00830
Retinol metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.98370
RefSeq NM_030622
HUGO
OMIM
CCDS CCDS12573
HPRD 07481
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca