Version 5.4
Homo sapiens Gene: ZFX
Summary
InnateDB Gene IDBG-52698.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFX
Gene Name zinc finger protein, X-linked
Synonyms ZNF926
Species Homo sapiens
Ensembl Gene ENSG00000005889
Encoded Proteins
IDBP-52700
zinc finger protein, X-linked
IDBP-52706
zinc finger protein, X-linked
IDBP-52708
zinc finger protein, X-linked
IDBP-52710
zinc finger protein, X-linked
IDBP-365686
zinc finger protein, X-linked
IDBP-365687
zinc finger protein, X-linked
IDBP-603541
zinc finger protein, X-linked
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:24149173-24216255
Strand Forward strand
Band p22.11
Transcripts
ENST00000379188 ENSP00000368486
ENST00000379177 ENSP00000368475
ENST00000304543 ENSP00000304985
ENST00000338565 ENSP00000343384
ENST00000428571 ENSP00000411637
ENST00000419690 ENSP00000416298
ENST00000497813
ENST00000459724
ENST00000480195
ENST00000474385
ENST00000539115 ENSP00000438233
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.336681 Hs.370424
RefSeq NM_001178084 NM_001178085 NM_001178086 NM_001178095 NM_003410 XM_005274591 XM_005274592 XM_005274594 XM_006724513 XM_006724514
HUGO
OMIM
CCDS CCDS14211 CCDS55390
HPRD 02445
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca