Version 5.4
Homo sapiens Gene: ARL1
Summary
InnateDB Gene IDBG-53147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARL1
Gene Name ADP-ribosylation factor-like 1
Synonyms ARFL1
Species Homo sapiens
Ensembl Gene ENSG00000120805
Encoded Proteins
IDBP-53149
ADP-ribosylation factor-like 1
IDBP-591341
ADP-ribosylation factor-like 1
IDBP-588424
ADP-ribosylation factor-like 1
IDBP-597810
ADP-ribosylation factor-like 1
IDBP-584601
ADP-ribosylation factor-like 1
IDBP-587390
ADP-ribosylation factor-like 1
IDBP-600808
ADP-ribosylation factor-like 1
IDBP-597121
ADP-ribosylation factor-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:101393120-101407820
Strand Reverse strand
Band q23.2
Transcripts
ENST00000261636 ENSP00000261636
ENST00000539055 ENSP00000439590
ENST00000536227 ENSP00000441808
ENST00000551688 ENSP00000447405
ENST00000550597
ENST00000551828 ENSP00000448850
ENST00000551671 ENSP00000448912
ENST00000551092 ENSP00000450162
ENST00000549283
ENST00000549302
ENST00000548070 ENSP00000450315
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 19 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005525 GTP binding
GO:0008047 enzyme activator activity
GO:0019001 guanyl nucleotide binding
GO:0019904 protein domain specific binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046872 metal ion binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0007030 Golgi organization
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0009404 toxin metabolic process
GO:0015031 protein transport
GO:0031584 activation of phospholipase D activity
GO:0034067 protein localization to Golgi apparatus
GO:0042147 retrograde transport, endosome to Golgi
GO:0048193 Golgi vesicle transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000060904
View Gene Order
ENSBTAG00000011883
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.372616 Hs.618679 Hs.707151
RefSeq NM_001177 NM_001301068 XM_005268869
HUGO
OMIM
CCDS CCDS44958 CCDS73510
HPRD 04574
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca