Version 5.4
| Homo sapiens Gene: PPY | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-53161.6 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | PPY | ||||||||||||
| Gene Name | pancreatic polypeptide | ||||||||||||
| Synonyms | PNP | ||||||||||||
| Species | Homo sapiens | ||||||||||||
| Ensembl Gene | ENSG00000108849 | ||||||||||||
| Encoded Proteins |
pancreatic polypeptide
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| Entrez Gene | |||||||||||||
| Summary |
This gene belongs to the NPY family and it encodes a protein that is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 17:43940804-43942468 | ||||||||||||
| Strand | Reverse strand | ||||||||||||
| Band | q21.31 | ||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
G alpha (i) signalling events pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
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| KEGG | |||||||||||||
| INOH |
GPCR signaling pathway
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| PID NCI | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | P01298 | ||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 5539 | ||||||||||||
| UniGene | Hs.558368 Hs.743907 | ||||||||||||
| RefSeq | NM_002722 | ||||||||||||
| HUGO | HGNC:9327 | ||||||||||||
| OMIM | 167780 | ||||||||||||
| CCDS | CCDS11472 | ||||||||||||
| HPRD | 01340 | ||||||||||||
| IMGT | |||||||||||||
| EMBL | BC032225 BC040033 M11726 M15788 X00491 | ||||||||||||
| GenPept | AAA60156 AAA60161 AAH32225 AAH40033 CAA25161 | ||||||||||||
| RNA Seq Atlas | 5539 | ||||||||||||