Version 5.4
Homo sapiens Gene: PLCB3
Summary
InnateDB Gene IDBG-53348.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLCB3
Gene Name phospholipase C, beta 3 (phosphatidylinositol-specific)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149782
Encoded Proteins
IDBP-53350
phospholipase C, beta 3 (phosphatidylinositol-specific)
IDBP-53352
phospholipase C, beta 3 (phosphatidylinositol-specific)
IDBP-589587
phospholipase C, beta 3 (phosphatidylinositol-specific)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:64251523-64269150
Strand Forward strand
Band q13.1
Transcripts
ENST00000325234 ENSP00000324660
ENST00000279230 ENSP00000279230
ENST00000540288 ENSP00000443631
ENST00000536243
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0003073 regulation of systemic arterial blood pressure
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016020 membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024960
View Gene Order
ENSBTAG00000012510
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19145
G beta:gamma signalling through PLC beta pathway
REACT_15426
PLC beta mediated events pathway
REACT_15295
Opioid Signalling pathway
REACT_21254
Presynaptic function of Kainate receptors pathway
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_18405
Acetylcholine regulates insulin secretion pathway
REACT_19193
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_172761
Ca2+ pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_13685
Neuronal System pathway
REACT_14797
Signaling by GPCR pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_15526
G-protein mediated events pathway
REACT_21312
Activation of Kainate Receptors upon glutamate binding pathway
REACT_19375
Free fatty acids regulate insulin secretion pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_111217
Metabolism pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04540
Gap junction pathway
hsa04310
Wnt signaling pathway pathway
hsa00562
Inositol phosphate metabolism pathway
hsa04720
Long-term potentiation pathway
hsa05010
Alzheimer's disease pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04730
Long-term depression pathway
hsa04020
Calcium signaling pathway pathway
hsa04916
Melanogenesis pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04062
Chemokine signaling pathway pathway
hsa05016
Huntington's disease pathway
hsa04971
Gastric acid secretion pathway
hsa05146
Amoebiasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
hsa05143
African trypanosomiasis pathway
INOH
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
INOH website
GPCR signaling pathway
INOH website
Inositol phosphate metabolism pathway
PID NCI
il8cxcr2_pathway
IL8- and CXCR2-mediated signaling events
lysophospholipid_pathway
LPA receptor mediated events
il8cxcr1_pathway
IL8- and CXCR1-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.523761
RefSeq NM_000932 NM_001184883 XM_005274052
HUGO
OMIM
CCDS CCDS53654 CCDS8064
HPRD 02577
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca