InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ESRRA

Summary

InnateDB Gene

IDBG-53564.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ESRRA

Gene Name

estrogen-related receptor alpha

Synonyms

ERR1; ERRa; ERRalpha; ESRL1; NR3B1

Species

Homo sapiens

Ensembl Gene

ENSG00000173153

Encoded Proteins

IDBP-53566

estrogen-related receptor alpha

IDBP-295255

estrogen-related receptor alpha

IDBP-295251

estrogen-related receptor alpha

IDBP-601870

estrogen-related receptor alpha

IDBP-598701

estrogen-related receptor alpha

IDBP-600059

estrogen-related receptor alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:64305572-64316743

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000000442	ENSP00000000442
ENST00000406310	ENSP00000385971
ENST00000405666	ENSP00000384851
ENST00000468670	ENSP00000441970
ENST00000467987
ENST00000539594	ENSP00000439896
ENST00000545035	ENSP00000444710

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	55 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0030278	regulation of ossification
GO:0030522	intracellular receptor signaling pathway
GO:0042127	regulation of cell proliferation
GO:0043401	steroid hormone mediated signaling pathway
GO:0045667	regulation of osteoblast differentiation
GO:0045670	regulation of osteoclast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051216	cartilage development