InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IFNA21

Summary

InnateDB Gene

IDBG-53575.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFNA21

Gene Name

interferon, alpha 21

Synonyms

IFN-alphaI; LeIF F; leIF-F

Species

Homo sapiens

Ensembl Gene

ENSG00000137080

Encoded Proteins

IDBP-53577

interferon, alpha 21

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:21165637-21166660

Strand

Reverse strand

Band

p21.3

Transcripts

ENST00000380225

ENSP00000369574

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005132	type I interferon receptor binding

Biological Process

GO:0002250	adaptive immune response
GO:0002286	T cell activation involved in immune response
GO:0002323	natural killer cell activation involved in immune response
GO:0006952	defense response
GO:0006959	humoral immune response
GO:0007596	blood coagulation
GO:0019221	cytokine-mediated signaling pathway
GO:0030183	B cell differentiation
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0042100	B cell proliferation
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response
GO:0045343	regulation of MHC class I biosynthetic process
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway