Version 5.4
Homo sapiens Gene: CDC16
Summary
InnateDB Gene IDBG-53861.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC16
Gene Name cell division cycle 16 homolog (S. cerevisiae)
Synonyms ANAPC6; APC6; CUT9
Species Homo sapiens
Ensembl Gene ENSG00000130177
Encoded Proteins
IDBP-53863
cell division cycle 16 homolog (S. cerevisiae)
IDBP-53865
cell division cycle 16 homolog (S. cerevisiae)
IDBP-53869
cell division cycle 16 homolog (S. cerevisiae)
IDBP-53871
cell division cycle 16 homolog (S. cerevisiae)
IDBP-53875
cell division cycle 16 homolog (S. cerevisiae)
IDBP-53877
cell division cycle 16 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:114234887-114272723
Strand Forward strand
Band q34
Transcripts
ENST00000360383 ENSP00000353549
ENST00000252457 ENSP00000252457
ENST00000356221 ENSP00000348554
ENST00000375310 ENSP00000364459
ENST00000375308 ENSP00000364457
ENST00000252458 ENSP00000252458
ENST00000494766
ENST00000484907
ENST00000494581
ENST00000461716
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 94 experimentally validated interaction(s) in this database.
Experimentally validated
Total 94 [view]
Protein-Protein 92 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007067 mitotic nuclear division
GO:0007088 regulation of mitosis
GO:0007094 mitotic spindle assembly checkpoint
GO:0008283 cell proliferation
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051301 cell division
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070979 protein K11-linked ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005876 spindle microtubule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038416
View Gene Order
ENSBTAG00000019971
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_1072
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_1041
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
REACT_6761
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_6820
APC/C:Cdc20 mediated degradation of Cyclin B pathway
REACT_6871
APC/C:Cdc20 mediated degradation of Securin pathway
REACT_6781
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_6904
Phosphorylation of the APC/C pathway
REACT_6785
Autodegradation of Cdh1 by Cdh1:APC/C pathway
REACT_6867
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_120956
Cellular responses to stress pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_6954
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_2137
Mitotic Spindle Checkpoint pathway
REACT_6900
Immune System pathway
REACT_910
M Phase pathway
REACT_169274
Cellular Senescence pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa04110
Cell cycle pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04114
Oocyte meiosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001078645 NM_003903 XM_005266204 XM_006719992 XM_006719993
HUGO
OMIM
CCDS CCDS9542
HPRD 04587
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca