InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAB3

Summary

InnateDB Gene

IDBG-53967.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAB3

Gene Name

TGF-beta activated kinase 1/MAP3K7 binding protein 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000157625

Encoded Proteins

IDBP-53969

TGF-beta activated kinase 1/MAP3K7 binding protein 3

IDBP-53971

TGF-beta activated kinase 1/MAP3K7 binding protein 3

IDBP-53973

TGF-beta activated kinase 1/MAP3K7 binding protein 3

IDBP-53975

TGF-beta activated kinase 1/MAP3K7 binding protein 3

IDBP-586946

TGF-beta activated kinase 1/MAP3K7 binding protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 15327770

MAP3K7IP3 (TAB3) and MAP3K7IP2 (TAB2) activate the NF-kappaB pathway through binding to K63-linked polyubiquitin chains.

PMID 14670075

MAP3K7IP3 (TAB3) and MAP3K7IP2 (TAB2) phosphorylation is mediated by SAPK2a/p38alpha and this contributes to the SAPK2a/p38alpha-mediated feedback control of MAP3K7 (TAK1) activity that also involves the phosphorylation of MAP3K7IP1 (TAB1).

PMID 14633987

MAP3K7IP3 (TAB3) and MAP3K7IP2 (TAB2) function redundantly as mediators of MAP3K7 (TAK1) activation in IL-1 and TNF signal transduction.

Entrez Gene

Summary

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:30827442-30975084

Strand

Reverse strand

Band

p21.2

Transcripts

ENST00000378933	ENSP00000368215
ENST00000288422	ENSP00000288422
ENST00000378932	ENSP00000368214
ENST00000378930	ENSP00000368212
ENST00000378928
ENST00000467136	ENSP00000433193

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0007254	JNK cascade
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051403	stress-activated MAPK cascade
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway