Version 5.4
| Homo sapiens Gene: SLC22A12 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-54113.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | SLC22A12 | ||||||||||||||||||
| Gene Name | solute carrier family 22 (organic anion/urate transporter), member 12 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000197891 | ||||||||||||||||||
| Encoded Proteins |
solute carrier family 22 (organic anion/urate transporter), member 12
solute carrier family 22 (organic anion/urate transporter), member 12
solute carrier family 22 (organic anion/urate transporter), member 12
solute carrier family 22 (organic anion/urate transporter), member 12
solute carrier family 22 (organic anion/urate transporter), member 12
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 11:64590641-64602353 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q13.1 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Organic anion transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
Transmembrane transport of small molecules pathway
Organic cation/anion/zwitterion transport pathway
SLC-mediated transmembrane transport pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q96S37 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 116085 | ||||||||||||||||||
| UniGene | Hs.174424 Hs.690995 Hs.742477 | ||||||||||||||||||
| RefSeq | NM_001276326 NM_001276327 NM_144585 NM_153378 | ||||||||||||||||||
| HUGO | HGNC:17989 | ||||||||||||||||||
| OMIM | 607096 | ||||||||||||||||||
| CCDS | CCDS60835 CCDS60836 CCDS8075 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB050269 AB071863 AC044790 AK315061 AP001092 AY358183 BC053348 CH471076 DQ514593 DQ514594 DQ514595 DQ514596 | ||||||||||||||||||
| GenPept | AAH53348 AAK68156 AAQ88550 ABF74570 ABF74571 ABF74572 ABF74573 BAB68364 BAB96750 EAW74273 EAW74274 | ||||||||||||||||||
| RNA Seq Atlas | 116085 | ||||||||||||||||||