InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IFNA1

Summary

InnateDB Gene

IDBG-54276.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFNA1

Gene Name

interferon, alpha 1

Synonyms

IFL; IFN; IFN-ALPHA; IFN-alphaD; IFNA@; IFNA13

Species

Homo sapiens

Ensembl Gene

ENSG00000197919

Encoded Proteins

IDBP-54278

interferon, alpha 1

IDBP-806483

interferon, alpha 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 15883164

IFNA1 activates NF-kappaB in JAK1-deficient cells through a TYK2-dependent pathway where for the IFN signalling pathway leading to STAT activation, both JAK1 and TYK2 are essential, but NF-kappaB activation requires only TYK2.

PMID 12817009

IFNA1 induces the human anti-inflammatory cytokine IL-10 gene via a module consisting of interdependent IRF1 and STAT3 motifs.

PMID 15699120

IFNA1 sensitizes cells to microbial recognition by up-regulating the expression of several TLRs as well as adapter molecules and kinases involved in TLR signalling.

PMID 9737881

IFNA1 is a type I interferon (IFN) that binds to the IFN receptor (IFNAR), composed of two transmembrane polypeptides, IFNAR1 and IFNAR2;IL10RB.

Entrez Gene

Summary

The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:21409169-21441316

Strand

Forward strand

Band

p21.3

Transcripts

ENST00000276927	ENSP00000276927
ENST00000613815	ENSP00000485003

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	3 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005132	type I interferon receptor binding

Biological Process

GO:0002250	adaptive immune response
GO:0002286	T cell activation involved in immune response
GO:0002323	natural killer cell activation involved in immune response
GO:0006952	defense response
GO:0006959	humoral immune response
GO:0007596	blood coagulation
GO:0019221	cytokine-mediated signaling pathway
GO:0030183	B cell differentiation
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0042100	B cell proliferation
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)
GO:0045343	regulation of MHC class I biosynthetic process
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway