InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TXNRD1

Summary

InnateDB Gene

IDBG-54357.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TXNRD1

Gene Name

thioredoxin reductase 1

Synonyms

GRIM-12; TR; TR1; TRXR1; TXNR

Species

Homo sapiens

Ensembl Gene

ENSG00000198431

Encoded Proteins

IDBP-54359

thioredoxin reductase 1

IDBP-54361

thioredoxin reductase 1

IDBP-234641

thioredoxin reductase 1

IDBP-382280

thioredoxin reductase 1

IDBP-485107

thioredoxin reductase 1

IDBP-598922

thioredoxin reductase 1

IDBP-591054

thioredoxin reductase 1

IDBP-586228

thioredoxin reductase 1

IDBP-585008

thioredoxin reductase 1

IDBP-599512

thioredoxin reductase 1

IDBP-602951

thioredoxin reductase 1

IDBP-589562

thioredoxin reductase 1

IDBP-597327

thioredoxin reductase 1

IDBP-586153

thioredoxin reductase 1

IDBP-596825

thioredoxin reductase 1

IDBP-595658

thioredoxin reductase 1

IDBP-597152

thioredoxin reductase 1

IDBP-596297

thioredoxin reductase 1

IDBP-587087

thioredoxin reductase 1

IDBP-587356

thioredoxin reductase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3\' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:104215779-104350305

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000354940	ENSP00000347020
ENST00000388854	ENSP00000373506
ENST00000397736	ENSP00000380844
ENST00000429002	ENSP00000412045
ENST00000503506	ENSP00000421934
ENST00000525566	ENSP00000434516
ENST00000534282
ENST00000526006
ENST00000526266	ENSP00000431294
ENST00000526691	ENSP00000435929
ENST00000531691	ENSP00000431925
ENST00000526390	ENSP00000435123
ENST00000531689	ENSP00000433507
ENST00000529546	ENSP00000434919
ENST00000529751	ENSP00000432273
ENST00000526207
ENST00000528079	ENSP00000433732
ENST00000526580	ENSP00000433887
ENST00000529784	ENSP00000436229
ENST00000524698	ENSP00000433425
ENST00000527688	ENSP00000433935
ENST00000527335	ENSP00000433599
ENST00000526950	ENSP00000432812
ENST00000525265

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004791	thioredoxin-disulfide reductase activity
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0016491	oxidoreductase activity
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0001707	mesoderm formation
GO:0007165	signal transduction
GO:0007369	gastrulation
GO:0008033	tRNA processing
GO:0008283	cell proliferation
GO:0015949	nucleobase-containing small molecule interconversion
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045454	cell redox homeostasis
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process